Effects of Dietary Nitrate in Women With Secondary Amenorrhea

Inclusion Criteria: * Women age 18-44 years old * Missed \>3 consecutive periods in the last 12 months if previously regularly menstruating (average cycle 21-35 d) OR * Missed \>6 consecutive periods in the last 12 month if previously irregularly menstruating (spontaneous menstruation, average cycle \<21 or \> 35 d) Exclusion Criteria: * Unable to provide informed consent * Currently diagnosed with primary amenorrhea (no history of menstruation by age 15) or oligomenorrhea (menstrual cycle \>35 d or \<8 cycles per year) * Currently diagnosed with a chronic illness, including thyroid disease, hyperprolactinemia, Cushing syndrome, and/or poly-cystic ovarian syndrome (PCOS) * History or current clinical diagnosis of an eating disorder * Currently dieting * Weight instablility for the past 3 months * Previously undergone a revascularization procedure involving a vascular graft or stenting of the femoral or popliteal arteries * Currently at the time of screening, or in the past year, using hormonal contraceptives * Pregnancy * Epilepsy * Current antibiotic use * Current nicotine user * Stage II hypertension (resting blood pressure \>140/\>90) * Currently taking proton pump inhibitors, antacids, xanthine oxidase inhibitors, or on hormone replacement therapy * An answer of yes to any of the seven questions on the first page of the Physical Activity Readiness Questionnaire (PAR-Q) indicating that the participant is not physically ready for exercise without a medical exam. These ex…