This experimental study aims to investigate the pathogenesis of bronchiolitis obliterans syndrome (BOS) and provide a basis for clinical diagnosis and treatment. The core research question is: whether there is a causal relationship between stem cell dysfunction induced by the inflammatory microenvironment and airway injury repair during the pathological process of BOS? Researchers will collect alveolar lavage fluid specimens from participants and healthy individuals to isolate distal small airway stem cells for subsequent scientific research and comparative analysis, thereby revealing the pathological mechanisms of BOS, exploring precise intervention targets, and developing innovative therapeutic strategies to improve patient prognosis, long-term survival rates, and quality of life.
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The self - renewal ability of airway basal cells
Timeframe: From enrollment to 32 weeks
Differentiation ability of airway basal cells
Timeframe: From enrollment to 32 weeks
Survival rate of ferret experiments
Timeframe: From enrollment to 32 weeks
Weight changes in ferret experiments
Timeframe: From enrollment to 32 weeks