CompletedNot Applicable

Efficacy of Leuconostoc Mesenteroides

South Korea28 participantsStarted 2024-08-13

Plain-language summary

Excessive alcohol intake can cause dehydration, digestive issues, oxidative stress, and hangover symptoms like headache and fatigue. Toxic metabolites like acetaldehyde and ROS contribute to liver damage. Chronic drinking activates harmful pathways like MEOS and increases inflammation. Gut-liver axis disruption also worsens hangovers. Probiotics, such as Leuconostoc mesenteroides, may help restore gut health and reduce toxicity, but more clinical research is needed.

Who can participate

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion * Healthy adults aged between 30 and 60 years * Body Mass Index (BMI) between 18.5 and 30 kg/m² * Individuals with a history of hangover experience * Adults with normal results in blood tests and vital signs * No organic gastrointestinal disease found in endoscopy within the past 3 months * Able to consume one bottle of soju within 30 minutes * Individuals who have personally signed the informed consent form Exclusion * Individuals who have consumed excessive alcohol within the past week * Individuals who participated in a human clinical trial within the past month * Individuals taking supplements or medications that may affect alcohol metabolism * Individuals with alcohol metabolism disorders, diabetes, hypertension, gallstones, pancreatitis, gout, active tuberculosis, gastrointestinal bleeding or surgery, or those with kidney, liver (e.g., hepatitis B/C carriers, alcoholic liver disease), heart, lung, gastrointestinal, or neurological diseases * Pregnant women or those planning to become pregnant * Individuals who have taken liver function supplements or similar medications/health products within one month before the study * Individuals who consumed excessive alcohol within one week prior to study participation * Any other individuals deemed unsuitable for the study by the principal investigator

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Assessment of Hangover Severity (Score, 0-10) Using the Alcohol Hangover Severity Scale (AHSS)

Timeframe: About 6 month

Change in Blood Ethanol (mg/dL) and Acetaldehyde (mg/dL) Levels Over Time

Timeframe: 6 month

Change in Blood Aldehyde Dehydrogenase (ALDH) Activity (mU/mL) Over Time

Timeframe: 6 month

Trial details

NCT IDNCT07017088

SponsorWonju Severance Christian Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-09-13

View on ClinicalTrials.gov More Alcohol Drinking trials

Plain-language summary

Who can participate

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Assessment of Hangover Severity (Score, 0-10) Using the Alcohol Hangover Severity Scale (AHSS)

Timeframe: About 6 month

Change in Blood Ethanol (mg/dL) and Acetaldehyde (mg/dL) Levels Over Time

Timeframe: 6 month

Change in Blood Aldehyde Dehydrogenase (ALDH) Activity (mU/mL) Over Time

Timeframe: 6 month