Excessive alcohol intake can cause dehydration, digestive issues, oxidative stress, and hangover symptoms like headache and fatigue. Toxic metabolites like acetaldehyde and ROS contribute to liver damage. Chronic drinking activates harmful pathways like MEOS and increases inflammation. Gut-liver axis disruption also worsens hangovers. Probiotics, such as Leuconostoc mesenteroides, may help restore gut health and reduce toxicity, but more clinical research is needed.
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Assessment of Hangover Severity (Score, 0-10) Using the Alcohol Hangover Severity Scale (AHSS)
Timeframe: About 6 month
Change in Blood Ethanol (mg/dL) and Acetaldehyde (mg/dL) Levels Over Time
Timeframe: 6 month
Change in Blood Aldehyde Dehydrogenase (ALDH) Activity (mU/mL) Over Time
Timeframe: 6 month