Role of Manuka Honey in Lowering Pain and Boosting Healing After Gum Graft Surgery. (NCT07016373) | Clinical Trial Compass
Not Yet RecruitingPhase 2
Role of Manuka Honey in Lowering Pain and Boosting Healing After Gum Graft Surgery.
Canada24 participantsStarted 2025-06-20
Plain-language summary
The goal of this clinical trial is to learn if medical grade Manuka Honey works to lower pain and improve healing sites after gum grafting surgery. The main questions are:
* Does medical grade Manuka honey lower pain and painkiller use after gum grafting surgery ?
* Does medical grade Manuka honey boost healing after gum grafting surgery ?
Researchers will compare, within the same patient, the results of a surgery with the application of Manuka honey in a retainer to a surgery without the application of honey in the retainer for the healing period.
Participants will:
* Visit the clinic for their first surgery.
* Fill up a daily survey to explain their level of pain and the amount of painkiller drugs used.
* Visit the clinic once every week for 6 weeks for follow-ups.
* Visit the clinic for their second surgery, four weeks after the first one.
* Fill up a daily survey to explain their level of pain and the amount of painkiller drugs used after the second surgery.
* Visit the clinic once every week for 6 weeks for follow-ups on the second surgery
* Fill a survey to compare both surgeries .
* Visit the clinic 2 months, 6 months and one year after the surgeries for more follow-ups.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
Participants must :
* Be 18 years of age or older.
* Be in good systemic health or have well-controlled systemic health.
* Have a healthy or stable periodontium after conventional periodontal treatment.
* Have good clinical gingival health or gingivitis on an intact or reduced periodontium, with or without a history of periodontitis
* Maintain good oral hygiene.
* Have a simplified plaque index and gingival bleeding index below 20%
* Require two mucogingival surgeries involving bilateral epithelial-conjunctival graft harvesting (free gingival graft or de-epithelialised connective tissue graft).
* The surgeries must treat single or multiple gingival recessions, or mucogingival defects around teeth or implants.
Exclusion Criteria:
* Smokers or users of other tobacco products
* Pregnant participants
* Participants who are uncooperative or have a psychological condition that makes free and informed consent or compliance with instructions impossible
* Participants with a condition that impairs healing (e.g. poorly controlled diabetes, coagulation disorder, etc.) or the objective assessment of pain at the sampling site (e.g. autoimmune diseases, orofacial pain, etc.)
* Participants regularly taking the following medications : non-steroidal anti-inflammatory drugs, bisphosphonates, sedatives, psychotropic drugs and corticosteroids.
* During the study, those who develop a condition that interferes with healing, become smokers, start medication that acts on the…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Patient Pain Level
Timeframe: Pain levels will be assessed daily for 14 days
2
Daily Ibuprofen Intake
Timeframe: Pain levels will be assessed daily for 14 days