CompletedPhase 1

A Study to Understand How the Study Medicine (PF-07976016) is Processed and Eliminated in Healthy Men

Netherlands8 participantsStarted 2025-06-04

Plain-language summary

The purpose of this study is to learn about how much the study medicine PF-07976016 will be taken up and processed by healthy male participants. The total number of weeks of the study is up to approximately 12 weeks.

Who can participate

Age range

18 Years – 65 Years

Sex

MALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Males, 18 to 65 years of age * BMI 17.5 to 32 kg/m2 and a total body weight \>50 kg (110 lb) * Willing and able to comply with all study procedures Exclusion Criteria: * History of irregular bowel movements or lactose intolerance * Any medical or psychiatric condition or laboratory abnormality or other condition that may increase the risk of study participation * Use of any prohibited or concomitant medication(s) * Presence of specified abnormalities on diagnostic assessments including clinical laboratory tests * Positive urine drug test * History of alcohol abuse or repeated binge drinking and/or any other illicit drug use or dependence * Use of tobacco/nicotine containing products in excess of the equivalent of 5 cigarettes/day * Previous administration of an investigational product within 30 days preceding the first dose of study medicine in this study.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Total recovery of radioactivity expressed as a percent of total oral radioactive dose administered.

Timeframe: From dose (Day 1) and for up to 21 days thereafter

Trial details

NCT IDNCT07015918

SponsorPfizer

Sponsor typeINDUSTRY

Study typeINTERVENTIONAL

Primary completion2025-07-16

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