Effects of Magnesium L-Threonate on Sleep, Recovery, and Athletic Performance in Collegiate Athletes (NCT07015047) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Effects of Magnesium L-Threonate on Sleep, Recovery, and Athletic Performance in Collegiate Athletes
United States100 participantsStarted 2025-10-01
Plain-language summary
This study is testing whether a special form of magnesium called magnesium L-threonate can help improve sleep quality, recovery, and physical performance in college athletes. Magnesium is important for muscle recovery and sleep, but many forms of it do not enter the brain well. Magnesium L-threonate is unique in that it can cross the blood-brain barrier and may improve deep and REM sleep, heart rate variability, and brain recovery.
In this study, healthy UCLA varsity athletes aged 18 to 35 will be randomly assigned to take either magnesium L-threonate or a placebo each evening for 4 weeks. They will wear a WHOOP strap to track sleep, recovery, and heart rate data. Performance tests including jump height, grip strength, and reaction time will be completed before and after the 4-week period.
This study will help researchers determine if this supplement can support recovery and training in athletes and whether wearable technology can help monitor these changes in real time.
Who can participate
Age range
18 Years – 35 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* • Age 18-35 years
* Current UCLA varsity athlete (any sport)
* Actively training or competing during the study period
* Willing to wear a WHOOP strap continuously for 4 weeks
* Willing to ingest a nightly capsule for 4 weeks
* Able to provide informed consent and comply with study procedures
Exclusion Criteria:
* • Current use of magnesium supplements or investigational drugs
* Use of prescription or over-the-counter sleep medications
* Diagnosed sleep disorder (e.g., insomnia, sleep apnea)
* Major medical condition limiting training or participation
* Pregnancy or breastfeeding
* Known history of chronic kidney or liver disease
* Allergy or intolerance to magnesium
* Inability to comply with study procedures (e.g., wearing WHOOP or completing surveys)
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in Deep Sleep Duration (minutes) from Baseline to Week 4
Timeframe: Baseline to Week 4
2
Change in Heart Rate Variability (HRV) from Baseline to Week 4