Autologous Serum Obtained by a Closed-Circuit Collection Device

Inclusion Criteria: * ≥ 18 years * Dry eye and/or chronic epithelial defects of the ocular surface with indication for autologous serum according to the evaluation of ophthalmologists specialized in Cornea and Ocular Surface; * Peripheral venous access or PICC that allows the collection of whole blood. Exclusion Criteria: * Active ocular infection; * Hemoglobin \< 11 g/dL; * Angina, MI, or stroke in the last 30 days; * Significant pulmonary or cardiac disease that contraindicates autologous serum collection in the investigator's opinion; * Active ocular or systemic infection at the time of collection; * Inability to attend follow-up visits at 6 and 12 weeks; * Active hematological malignancy (except measurable residual disease) or solid malignancy (except non-melanoma skin cancer); * Positive for HIV, HCV, HBV, HTLV, Chagas disease, or syphilis; * Life expectancy \< 6 months; * Not pregnant (as reported by the participant).