Active — Not RecruitingNot Applicable

Brain Alterations Based on Multiplex MR Imaging in Nasopharyngeal Carcinoma Patients After Treatment, and Their Correlation With Clinical Cognitive Scores.

China60 participantsStarted 2023-04-01

Plain-language summary

The objective of this study is to examine the potential impact of the treatment before, during, and/or after radiotherapy on the brain in patients with nasopharyngeal carcinoma (NPC) using Multiplex (MTP) MR imaging sequence, which generate multiple contrasts with one-time scan. We aimed to investigate the altered MTP parameters and their correlation with clinical cognitive scores before and after the treatment.

Who can participate

Age range30 Years – 80 Years

SexALL

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Inclusion Criteria: * pathological evidence of NPC (stages III-IV at diagnosis according to the 8th edition of the UICC/AJCC staging system for NPC) * right-handed * prepared to receive treatments * prepared to receive the Montreal Cognitive Assessment (MoCA) Exclusion Criteria: * brain invasion * brain tumor or atrophy, neural-associated diseases, a history of brain surgery * any current medications that may affect cognitive function * inability to attend MRI scanning

What they're measuring

volume

Timeframe: 3 months

Trial details

NCT IDNCT07011329

SponsorHubei Cancer Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-12-31

View on ClinicalTrials.gov More Nasopharyngeal Carcinoma (NPC) trials