Not Yet RecruitingNot Applicable

Effect of Intraperitoneal Insulin Administration After Laparoscopy in Insulin-Resistant Patients on Prevention of Postoperative Adhesion Recurrence: A Randomized Controlled Trial

100 participantsStarted 2025-06-01

Plain-language summary

Adhesion formation following laparoscopic pelvic surgery remains a significant cause of chronic pelvic pain, infertility, and surgical complications. Patients with insulin resistance (IR) may have heightened inflammatory responses and impaired tissue healing, contributing to a higher risk of adhesion formation. Intraperitoneal administration of insulin has shown promising results in animal models by modulating inflammatory mediators and enhancing fibrinolysis. This trial aims to evaluate the efficacy and safety of intraperitoneal insulin instillation at the end of laparoscopy in women with insulin resistance.

Who can participate

Age range18 Years – 50 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Women aged 18-40 years * Diagnosed insulin resistance (e.g., HOMA-IR \>2.5 or fasting insulin \>15 uIU/mL) * Indicated for laparoscopy for infertility or pelvic pain * BMI 20-35 kg/m² * Able and willing to give informed consent Exclusion Criteria: * Diabetes mellitus requiring pharmacologic treatment * History of peritonitis or major abdominal surgery in the past 6 months * Known allergy or sensitivity to insulin * Chronic steroid or immunosuppressive use * Pregnancy or lactation * Participation in another clinical trial within the last 3 months

What they're measuring

Adhesion scoring at second-look laparoscopy

Timeframe: 4-6 weeks postoperatively

Trial details

NCT IDNCT07007130

SponsorAin Shams University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-03-01

View on ClinicalTrials.gov More Prevention of Postoperative Adhesions trials