REACH Study (Recovery Environments: Assessing Cognitive & Brain Health in Community Mental Health) (NCT07006935) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
REACH Study (Recovery Environments: Assessing Cognitive & Brain Health in Community Mental Health)
United States30 participantsStarted 2026-06-01
Plain-language summary
The purpose of this study is to understand how different types of community-based mental health care affect thinking abilities, daily functioning, and brain activity in adults with schizophrenia and related conditions. The investigators are especially interested in learning whether the Clubhouse Model-a structured, supportive community for individuals with mental illness-has unique benefits compared to standard outpatient mental health services. If participants decide to join, they will be asked to complete a total of six study visits with the research team over the course of your participation. Three of these study visits are at the beginning (baseline) and the remaining three are six months later. Two of the three visits will includes interviews, questionnaires, and thinking and memory tasks (cognitive testing) and one session will be an MRI brain scan, which is a safe and non-invasive imaging procedure. The total time required for each visit will be approximately 90 minutes to two hours. Participants may take breaks as needed.
Who can participate
Age range
18 Years – 50 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* (1) have a DSM-V diagnosis of schizophrenia, schizoaffective disorder, or schizophreniform confirmed by diagnostic assessment and medical record review
* (2) between the ages of 18-50
* (3) stabilized on psychotropic medication as indicated by no changes to the primary psychiatric medication in the last month
* (4) able to read and speak fluent English at a sixth grade level or higher for purposes of informed consent and cognitive testing
* For Clubhouse members, they must be a first-time, newly enrolled member
Exclusion Criteria:
* (1) had previous membership at a Clubhouse (Magnolia or elsewhere)
* (2) have a current severe substance use disorder
* (3) have persistent suicidal or homicidal behavior
* (4) a co-occurring diagnosis of an intellectual or learning disability or neurodevelopment condition (e.g., Autism; based on chart review)
* (5) had recent psychiatric instability requiring hospitalization in the past month;
* (6) history of a traumatic brain injury (TBI; based on record review)
* (7) contraindicators for MRI (e.g., pacemaker, claustrophobia)
* Participants in the usual care will be excluded if they are a current Clubhouse member or join a Clubhouse during participation in this research
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in overall cognitive performance as measured by MATRICS Consensus Cognitive Battery (MCCB)
Timeframe: Baseline and 6 months
2
Change in functional outcome as measured by Specific Levels of Functioning Scale (SLOF)
Timeframe: Baseline and 6 months
3
Change in quality of life as measured by World Health Organization Quality of Life Brief Assessment (WHOQOL-BREF)
Timeframe: Baseline and 6 months
4
Change in disability as measured by the 12-item WHO Disability Assessment Schedule 2.0 (WHODAS 2.0
Timeframe: Baseline and 6 months
5
Change in task-based brain activation during functional MRI (fMRI) as measured by the AX-Continuous Performance Task (AX-CPT)
Timeframe: Baseline and 6 months
6
Change in task-based brain activation during functional MRI (fMRI) as measured by the Emotional Faces N-Based Task (EFNBACK)