Not Yet RecruitingNot Applicable

Brain Olfactory Pathways in Prader-Willi Syndrome

France30 participantsStarted 2025-06-23

Plain-language summary

Studying the cerebral activity of children with Prader-Willi Syndrom (PWS) when the study propose to them nasal activations.

Who can participate

Age range5 Years – 7 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * child with a genetically confirmed diagnosis of PWS and for whom the genetic subtype (deletion or non deletion) has been identified * Child aged between 5 and 7 years * Child with a planned hospitalization at the Toulouse reference center for PWS Exclusion Criteria: * Presence of a contraindication to MRI * Allergy to any of the fragrances used in the olfactory test * Presence of an ENT infection such as rhinitis or sinusitis on the day of inclusion * Reported anosmia * Administrative problems.

What they're measuring

hyperactivation of the right amygdala in young children with PWS not early OT-exposed and aged between 5 and 7 years in response to a sweet food odor compared to a neutral non-food odor.

Timeframe: day 1

Trial details

NCT IDNCT07006207

SponsorUniversity Hospital, Toulouse

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-12

Contact for this trial

Julie CORTADELLAS

0534557635 cortadellas.j@chu-toulouse.fr

View on ClinicalTrials.gov More Prader-Willi Syndrome trials