Not Yet RecruitingNot Applicable

Prognostic Value of Transcranial Doppler Ultrasound in the Clinical Evolution of Patients With Acute Ischemic Stroke. The TRADE-AIS Study

50 participantsStarted 2026-08-01

Plain-language summary

This prospective observational study aims to determine whether specific parameters measured by transcranial Doppler ultrasound (TCD) can predict clinical outcomes in patients with acute ischemic stroke (AIS). The primary objective is to evaluate the association between middle cerebral artery (MCA) flow velocities and short-term neurological improvement. Secondary outcomes include the presence of collateral flow and flow patterns in relation to functional recovery measured by NIHSS and modified Rankin Scale (mRS) scores.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age ≥ 18 years * Clinical diagnosis of acute ischemic stroke * Onset of symptoms ≤ 24 hours before admission * Underwent or will undergo transcranial Doppler ultrasound within 24 hours of symptom onset * Able to provide informed consent or consent obtained from a legal representative Exclusion Criteria: * Evidence of intracerebral hemorrhage on imaging * Inadequate temporal acoustic window for transcranial Doppler * Intubated or hemodynamically unstable prior to Doppler evaluation * Known diagnosis of neurodegenerative disease significantly affecting baseline neurological function (e.g., advanced dementia, Parkinson's disease) * Refusal to participate or withdrawal of consent

What they're measuring

Change in NIHSS score from baseline to 72 hours

Timeframe: 72 hours

Trial details

NCT IDNCT07004790

SponsorJose Ivan Rodriguez de Molina Serrano

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-07-31

Contact for this trial

JOSE IVAN RODRIGUEZ DE MOLINA SERRANO, MD, MSc, Ph, Crit Care sp

878 782 12 89 jefe.urgencias@clinicamexico.com