Microfluidics Versus Density Gradient Centrifugation for Sperm Preparation in IVF (NCT07004309) | Clinical Trial Compass
CompletedNot Applicable
Microfluidics Versus Density Gradient Centrifugation for Sperm Preparation in IVF
Vietnam119 participantsStarted 2023-03-14
Plain-language summary
This randomized controlled trial aimed to compare the effectiveness of microfluidic sperm sorting and density gradient centrifugation (DGC) in reducing sperm DNA fragmentation index (DFI) and improving clinical outcomes in IVF. A total of 119 couples underwent IVF and were assigned to either microfluidic or DGC sperm preparation. The study evaluated sperm quality, fertilization, embryo development, and live birth rates.
Who can participate
Age range18 Years – 40 Years
SexALL
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Inclusion Criteria:
* Female partner aged between 18 and 40 years
* Couples undergoing in vitro fertilization (IVF) cycles at the IVF and Tissue Engineering Center, Hanoi Medical University, between January 2022 and January 2024
* Use of autologous oocytes
* Use of ejaculated sperm
* Both partners provide written informed consent
Exclusion Criteria:
* Use of donor oocytes or donor sperm
* Requirement for testicular sperm extraction
* Diagnosis of oligoasthenozoospermia (OA) based on WHO 2021 criteria
* Female partner classified as having poor ovarian prognosis according to the POSEIDON 2016 criteria, including:
* Anti-Müllerian hormone (AMH) level \< 1.2 ng/mL
* Antral follicle count (AFC) \< 5
* Or history of poor ovarian response (≤9 oocytes retrieved in previous cycles)
* Preimplantation genetic testing (PGT) cycles