Neural Control and Mechanosensation in Spine Muscle (NCT07003802) | Clinical Trial Compass
By InvitationNot Applicable
Neural Control and Mechanosensation in Spine Muscle
United States152 participantsStarted 2025-07-01
Plain-language summary
Low back pain (LBP) is a condition that affects a majority of the US population and is responsible for a significant proportion of health care costs and utilization. Lumbar spine muscle is compromised in LBP, and do, and do not, respond to exercise based physical therapy program depending on measurements representing activation capacity of lumbar muscle. Here, we will characterize the neurological and muscle specific features that may contribute to limited activation in an attempt to identify sources of resistance to recovery in patients with chronic disc injury and identify precision rehabilitation approaches for this complex population of individuals.
Who can participate
Age range
18 Years – 60 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Surgical group:
* Individuals diagnosed with chronic disc injury (symptoms \> 3 months),
* Individuals planning to undergo a spinal surgery to address the diagnosis of chronic disc injury
Physical Therapy Group-
* Individuals diagnosed with chronic disc injury (symptoms \>3 months),
* Individuals initiating an exercise-based physical therapy program to address the diagnosis of chronic disc injury
Healthy Control group -
* Individuals with no history of chronic back pain (interfering pain lasting \>3 months) within the past 3 years,
* no significant spinal pathology beyond normal age-related degenerative changes
Exclusion Criteria:
* Surgery/Physical therapy groups-History of lumbar spine surgery
* Diabetes
* Neuromuscular diseases
* Epilepsy or other seizure disorder -Healthy control group -
* History of lumbar spine surgery
* History of interfering pain lasting \>3 months
* Diabetes
* Neuromuscular diseases
* Epilepsy or other seizure disorder
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.