By InvitationNot Applicable

Neural Control and Mechanosensation in Spine Muscle

United States152 participantsStarted 2025-07-01

Plain-language summary

Low back pain (LBP) is a condition that affects a majority of the US population and is responsible for a significant proportion of health care costs and utilization. Lumbar spine muscle is compromised in LBP, and do, and do not, respond to exercise based physical therapy program depending on measurements representing activation capacity of lumbar muscle. Here, we will characterize the neurological and muscle specific features that may contribute to limited activation in an attempt to identify sources of resistance to recovery in patients with chronic disc injury and identify precision rehabilitation approaches for this complex population of individuals.

Who can participate

Age range18 Years – 60 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Surgical group: * Individuals diagnosed with chronic disc injury (symptoms \> 3 months), * Individuals planning to undergo a spinal surgery to address the diagnosis of chronic disc injury Physical Therapy Group- * Individuals diagnosed with chronic disc injury (symptoms \>3 months), * Individuals initiating an exercise-based physical therapy program to address the diagnosis of chronic disc injury Healthy Control group - * Individuals with no history of chronic back pain (interfering pain lasting \>3 months) within the past 3 years, * no significant spinal pathology beyond normal age-related degenerative changes Exclusion Criteria: * Surgery/Physical therapy groups-History of lumbar spine surgery * Diabetes * Neuromuscular diseases * Epilepsy or other seizure disorder -Healthy control group - * History of lumbar spine surgery * History of interfering pain lasting \>3 months * Diabetes * Neuromuscular diseases * Epilepsy or other seizure disorder

What they're measuring

RMS amplitude of paraspinal muscle EMG

Timeframe: Baseline

IVIM responsiveness

Timeframe: Baseline

Cortical excitability

Timeframe: Baseline

pAMPK

Timeframe: Time of surgery/biopsy

Trial details

NCT IDNCT07003802

SponsorUniversity of California, San Diego

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2029-05-01

View on ClinicalTrials.gov More Low Back Pain and Core Muscle trials

Plain-language summary

Who can participate

Age range18 Years – 60 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.