CompletedPhase 3

Intraoperative Nebulization of Lidocaine and Postoperative Pulmonary Complications

China270 participantsStarted 2025-06-06

Plain-language summary

There is high incidence of postoperative pulmonary complications (PPCs) in patients undergoing major abdominal surgeries.PPCs significantly prolongs the hospital stay of patients, increases their economic burden, and raises the mortality rates within 30 days and 1 year after surgery. The inflammatory response during the perioperative period plays an important role in the occurrence and development of PPCs. The anti-inflammatory effect of lidocaine has a potential lung protection mechanism. The purpose of this study is to explore the effect of nebulization of lidocaine on the incidence of PPCs. The investigators hypothesized that intraoperative nebulization of lidocaine could reduce the incidence of PPCs.

Who can participate

Age range18 Years – 90 Years

SexALL

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Inclusion Criteria: * Patients who have signed the informed consent form and are willing to complete the study according to the protocol * Age ≥18 years old and ≤90 years old * ASA classification grades I-III * Elective major non-cardiac surgery * General anesthesia under tracheal intubation * Monitor invasive arterial blood pressure * The expected operation time ≥2 hours Exclusion Criteria: * Untreated ischemic heart disease Severe cardiovascular and cerebrovascular diseases * Severe asthma, pulmonary bullae, pneumothorax, bronchopleural fistula, etc * Severe underlying liver and kidney diseases * Age under 18 years old or over 90 years old * The expected operation time is ≥2 hours

What they're measuring

The incidence of PPCs within seven days after surgery

Timeframe: Up to one week

Trial details

NCT IDNCT07000760

SponsorJun Zhang

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-01-23