CompletedPhase 3

Intraoperative Nebulization of Lidocaine and Postoperative Pulmonary Complications

China270 participantsStarted 2025-06-06

Plain-language summary

There is high incidence of postoperative pulmonary complications (PPCs) in patients undergoing major abdominal surgeries.PPCs significantly prolongs the hospital stay of patients, increases their economic burden, and raises the mortality rates within 30 days and 1 year after surgery. The inflammatory response during the perioperative period plays an important role in the occurrence and development of PPCs. The anti-inflammatory effect of lidocaine has a potential lung protection mechanism. The purpose of this study is to explore the effect of nebulization of lidocaine on the incidence of PPCs. The investigators hypothesized that intraoperative nebulization of lidocaine could reduce the incidence of PPCs.

Who can participate

Age range

18 Years – 90 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients who have signed the informed consent form and are willing to complete the study according to the protocol * Age ≥18 years old and ≤90 years old * ASA classification grades I-III * Elective major non-cardiac surgery * General anesthesia under tracheal intubation * Monitor invasive arterial blood pressure * The expected operation time ≥2 hours Exclusion Criteria: * Untreated ischemic heart disease Severe cardiovascular and cerebrovascular diseases * Severe asthma, pulmonary bullae, pneumothorax, bronchopleural fistula, etc * Severe underlying liver and kidney diseases * Age under 18 years old or over 90 years old * The expected operation time is ≥2 hours

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

The incidence of PPCs within seven days after surgery

Timeframe: Up to one week

Trial details

NCT IDNCT07000760

SponsorJun Zhang

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-01-23

View on ClinicalTrials.gov More Postoperative Pulmonary Complications (PPCs) trials