Neurological dysfunction either transient or permanent is a major cause of morbidity and mortality after cardiopulmonary bypass, and cognitive dysfunction is more frequent in cardiac surgery than in non-cardiac procedures. Variations in cerebral blood flow and oxygen extraction are considered key contributing factors. Although pulsatile flow during bypass has shown benefits for renal function and recovery, its effects on postoperative neurological dysfunction and delirium remain unclear due to limited research. This study aims to evaluate the impact of pulsatile versus non-pulsatile cardiopulmonary bypass flow on POCD in adult CABG patients by measuring middle cerebral artery (MCA) flow using transcranial Doppler.
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Middle cerebral artery mean flow velocity measured by transcranial Doppler
Timeframe: Perioperative period
Postoperative delirium incidence (yes/no)
Timeframe: Postoperative days 1-5
Postoperative cognitive dysfunction (MMSE score change)
Timeframe: Postoperative day 5