CS-206 in Patients With Sickle Cell Disease

Inclusion criteria

• . At least 2 occurrences of any of the following events within 2 years prior to screening.
• . Acute pain crisis: requiring a visit to a medical facility and administration of pain medications (opioids or intravenous NSAIDs) or red blood cell transfusions.
• . Acute chest syndrome: defined by the presence of a new pulmonary infiltrate on a chest X-ray, associated with pneumonia-like symptoms, including chest pain, fever, or respiratory distress.
• . Priapism lasting more than 2 hours and necessitating a visit to a medical facility for intervention.
• . Stroke or transient ischemic attack (TIA): confirmed by imaging studies (e.g., MRI or CT scan), including silent stroke, and overt stroke leading to neurological deficits lasting \>24 hours.
• . Presence of red cell alloimmunization (\>2 antibodies) and the need for ongoing chronic transfusions.
• . Participants who have failed, not tolerated, refused the standard of care for Sickle Cell Disease (SCD), or are unable to access the standard of care due to the availability
• . Other situations deemed appropriate for hematopoietic stem cell transplantation according to the sickle cell anemia treatment guidelines, as determined by the investigator.

Exclusion criteria