The RECOVERY Study: Using Supersaturated Oxygen Therapy To Treat Small Vessel Blockages After a H… (NCT07000266) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
The RECOVERY Study: Using Supersaturated Oxygen Therapy To Treat Small Vessel Blockages After a Heart Attack
Spain20 participantsStarted 2025-05-23
Plain-language summary
The study tests whether adding supersaturated oxygen (SSOâ‚‚) therapy to standard stent treatment can improve heart recovery after a major heart attack (anterior STEMI). Adults treated within 6 hours of symptoms will be randomly assigned to receive either standard care or standard care plus SSOâ‚‚. The goal is to see if SSOâ‚‚ reduces damage to small heart vessels. Heart function will be checked immediately, after one hour, and again at six months. Follow-up visits will track recovery for up to a year.
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. The subject must be ≥ 18 years of age
✓. Anterior STEMI (ECG with persistent elevation ≥ 2 mm (0.2 mV) in 2 or more contiguous anterior precordial leads (V2, V3, V4) in men or ≥ 1.5 mm (0.15 mV) in women.
✓. Symptoms consistent with myocardial ischemia (persistent chest pain, dyspnea, nauseas/vomiting, fatigue, palpitations or syncope) present for ≤ 6 hours.
✓. Provision of informed consent by patient
✓. Culprit lesion in proximal or mid LAD.
✓. Pre-PCI TIMI flow 0-1.
✓. The patient is eligible for primary PCI.
✓. Successful PCI of a proximal or mid LAD lesion with commercially available coronary stents and achievement of TIMI 2 or 3 flow
Exclusion criteria
✕. Previous MI, PCI or CABG occurred before index procedure.
✕. Previous history of stroke, transient ischemic attack (TIA) or reversible ischemic neurological deficit within last 6 months.
✕. Known severe kidney disease (eGFR \<=30 mL/min/1.73) and/or hemodialysis.