Preoperative Pregabalin vs Gabapentin in Elderly Undergoing Surgry,Controlled Trial (NCT07000201) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Preoperative Pregabalin vs Gabapentin in Elderly Undergoing Surgry,Controlled Trial
Egypt84 participantsStarted 2025-09-15
Plain-language summary
Several studies have evaluated the efficacy of pregabalin in reducing preoperative anxiety, with inconsistent results. Similarly, inconclusive results have been reported regarding gabapentin and its effects in reducing preoperative anxiety. A previous study reported that a single dose of gabapentin or pregabalin administered 60 minutes before surgery in adults under general anesthesia was effective in reducing acute preoperative anxiety and elevated levels of sedation before and after surgery, with pregabalin having better anxiolytic and sedative effects than gabapentin. However, no previous studies have compared the efficacy of preoperative pregabalin or gabapentin as premedication to reduce intraoperative anxiety and induce sedation in geriatric patients undergoing major surgery with regional anesthesia
Who can participate
Age range65 Years
SexALL
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Inclusion criteria
✓. geriatric patients, aged 65 years or older,
✓. Both sex,
✓. scheduled for elective abdominopelvic surgery with regional anesthesia
✓. American Society of Anesthesiologists (ASA) physical status I or II.
Exclusion criteria
✕. history of allergy to gabapentin or pregabalin;
✕. current use of gabapentin or pregabalin for other indications
✕. history of chronic pain or chronic daily use of analgesics; a
✕. history of epilepsy, other neurological disorders, cognitive impairment, or severe psychiatric disorders;
✕. severe cardiovascular or respiratory diseases;
✕. impaired renal function; and a history of drug or alcohol abuse.
✕
What they're measuring
1
Intraoperative sedation levels are assessed using the Ramsay Sedation Scale .