RecruitingNot Applicable

Ketamine for Preventing Post-Spinal Hypotension in Orthopedic Surgery

Egypt30 participantsStarted 2025-06-01

Plain-language summary

This randomized, double-blind, controlled clinical trial investigates the efficacy of a sub-anesthetic dose of ketamine (0.5 mg/kg IV) in preventing post-spinal hypotension in patients undergoing elective orthopedic surgeries under spinal anesthesia. The study compares ketamine with placebo (normal saline) in terms of blood pressure stability and incidence of hypotensive episodes following spinal anesthesia.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients American Society of Anesthesiologists Physical Status (ASA) I to II undergoing orthopedic surgeries under spinal anesthesia. * Both Sexes. * Patients aged equal to or above 18 years. * Body mass index \<35 kg/m2 * Duration of operation from 1 hour to 3 hours Exclusion Criteria: * Patients' refusal of procedure or participation in the study. * Patients with contraindication to spinal anesthesia. * Patients with cardiovascular or pulmonary disease. * Patients with pre-procedural hypotension (systolic arterial pressure less than 90 mmHg and/or mean arterial pressure less than 60 mmHg). * Patients aged below 18 years. * Duration of operation below 1 hour or above 3 hours.

What they're measuring

Incidence of Post-Spinal Hypotension

Timeframe: From spinal injection to end of surgery

Trial details

NCT IDNCT06995690

SponsorAin Shams University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-10-01

Contact for this trial

Amira G Abdelmoniem Abdalla, M.B.B.Ch.

+201277719693 am.ga.ab.ab.mo@gmail.com

View on ClinicalTrials.gov More Post-spinal Hypotension trials