Not Yet RecruitingPhase 2

Effect of Topical Bromelain Versus Topical Corticosteroids in the Management of Recurrent Aphthous Stomatitis

63 participantsStarted 2025-06-15

Plain-language summary

Bromelain, a natural product, exhibits anti-inflammatory, immunomodulatory, and wound-healing properties. However, its efficacy in treating oral mucosal ulcers remains unexplored. This study aims to evaluate the effect of bromelain as a safe alternate for management of RAS.

Who can participate

Age range18 Years – 60 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adults aged 18-60 years. * Diagnosed with RAS. * Onset of ulcer within the last 48 hours. * Willingness to participate and provide informed consent. Exclusion Criteria: * History of hematological deficiencies, GIT disorders, Behcet's disease and major systemic diseases. * Pregnant or breastfeeding patients. * Previous treatment for the current ulcer episode.

What they're measuring

Pain associated with ulcers

Timeframe: Recorded at baseline, day 2, day 4 and day 7

Trial details

NCT IDNCT06993337

SponsorCairo University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-05-15

View on ClinicalTrials.gov More Recurrent Aphthous Stomatitis trials