Neuroprotection Bundles For Comatose Survivors Following Cardiac Arrest

Inclusion Criteria: * Age ≥ 18 years and \< 80 years * Patients of in-hospital or out-of-hospital cardiac arrest who have returned -spontaneous circulation (ROSC) after cardiopulmonary resuscitation and do not require CPR for more than 20 minutes; * Patients who are unconscious after ROSC, defined as FOUR motor response score \< 4 points or GSC ≤ 8 points; * Family members or legal representatives signed informed consent. Exclusion Criteria: * Unwitnessed cardiac arrest, estimated time from cardiac arrest to start of CPR \> 30 minutes; * Time from cardiac arrest to ROSC \> 60 minutes; * Patients who woke up immediately after ROSC by CPR; * End-stage diseases; * Cardiac arrest considered to be caused by neurological diseases; * The patient was in a vegetative state before cardiac arrest; * The interval from the onset of cardiac arrest to enrollment is \>72 hours .