Not Yet RecruitingNot Applicable

Network Pharmacology Was Applied to Explore the Mechanism of Remimazolam Applied in General Anesthesia for Gynecological Surgeries

40 participantsStarted 2025-06-01

Plain-language summary

To explore the related mechanisms by which remimazolam regulates hemodynamic stability, inflammatory factors and the immune system in patients undergoing general anesthesia for gynecological surgeries.

Who can participate

Age range18 Years – 64 Years

SexFEMALE

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Inclusion criteria

✓. The patient or their family members sign the informed consent form
✓. Age: 18-64 years old, BMI: 18-30kg/m2
✓. ASA Grade Ⅰ or Ⅱ
✓. Patients undergoing gynecological surgeries (laparoscopic total hysterectomy, adnexectomy and myomectomy)

Exclusion criteria

✕. People who are allergic to remimazolam or benzodiazepinesThyroid disease
✕. Long-term use of benzodiazepines
✕. Pregnancy or lactation
✕. Have a history of drug abuse or alcoholism
✕. Patients with contraindications for surgery
✕. Patients with hypertension (clinically diagnosed with hypertension) and patients with coronary heart disease (with typical angina pectoris symptoms and excluding aortic valve lesions, with a clear history of old myocardial infarction, with a clear history of acute myocardial infarction, and CAG finding coronary artery stenosis greater than or equal to 70%)
✕. Patients with arrhythmia, heart failure, renal failure, and those who have recently taken cardiovascular active drugs
✕. Endocrine disorders such as hyperthyroidism and pheochromocytoma that may affect the hemodynamic level of the body

What they're measuring

Levels of serum N/OFQ, IL-6, STAT3

Timeframe: perioperatively/periprocedurally

Trial details

NCT IDNCT06990763

SponsorSecond Hospital of Shanxi Medical University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-12-01

Contact for this trial

ran Zhang

17835158352 17835158352@163.com

View on ClinicalTrials.gov More Gynecological Disease trials