Methamphetamine and Troriluzole

Inclusion criteria

• . able to speak/read English,
• . not seeking treatment for drug use at the time of the study,
• . female or male between the ages of 18 and 55 years,
• . recent methamphetamine use verified by methamphetamine positive urine, as well as fulfillment of DSM-5 diagnostic criteria for MUD,
• . judged to be medically and psychiatrically healthy by study physicians other than the diagnosis for MUD (and OUD for the co-morbid MUD and OUD group, see below) at the time of screening,
• . ECG, read by a cardiologist, within normal limits,
• . females using an effective form of birth control and not pregnant or breastfeeding,
• . no known contraindications (e.g., hepatic disease \[save for asymptomatic HCV status as cleared by study physician\]) or allergies to troriluzole. Individuals in the MUD and OUD group must also report recent opioid use, verified by opioid positive urine, as well as fulfillment of DSM-5 diagnostic criteria for OUD with physiologic dependence (determined to not be physically dependent if a participant arrives with a urine sample for drug screening that is negative for a short-acting opioid and does not have a score of 5 or greater on the clinical opioid withdrawal scale \[COWS\]).

Exclusion criteria