Role of Inflammasome in Platelet Activation in Sickle Cell Disease Patient

Inclusion Criteria: * patients with SS or SC Sickle cell disease * diagnosis of SCD performed by electrophoresis or HPLC in a reference laboratory for hemoglobinopathies * clinically in a steady state at inclusion (without complication in the last month and without transfusion in the three last months) * patient followed up for Sickle cell disease at the sickle cell center of Guadeloupe (University hospital of Guadeloupe, Pointe à Pitre) * patients who will provide written informed consent in accordance with the Declaration of Helsinki * patients affiliated to national social security Exclusion Criteria: * \- patients with hemoglobinopathy other than SS and SC Sickle cell disease * patients with a transfusion therapy or on bleeding therapy for less than three months * patients no affiliated to national social security * pregnant or breastfeeding patients * patients who will not provide written informed consent in accordance with the Declaration of Helsinki