CompletedNot Applicable

ORI and ETCO₂ Relationship With Arterial Blood Gas During Apnea Test

Turkey (Türkiye)35 participantsStarted 2023-07-01

Plain-language summary

This observational study aims to evaluate the relationship between the Oxygen Reserve Index (ORI) and End-Tidal Carbon Dioxide (ETCO2) values with arterial blood gas parameters in patients undergoing the apnea test for the diagnosis of brain death. The study will examine the correlation between ORI and PaO2, as well as between ETCO2 and PaCO2. The primary objective is to assess the effectiveness of ORI in evaluating oxygenation and its applicability in the apnea test. The study will also evaluate the routine use of ORI in monitoring PaO2 and its potential benefits compared to traditional methods.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients who meet all the prerequisites for initiating the brain death diagnosis process and for whom the decision to perform the apnea test for diagnosis of brain death. * Patients aged 18 years or older. * Patients who have provided verbal and written consent from their first-degree relatives. Exclusion Criteria: * Patients whose first-degree relatives do not consent to participation in the study. * Patients in whom the ORI probe cannot be used due to circulatory disturbances in the extremities

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Since this study is already completed, can you tell me if the findings about the Oxygen Reserve Index during apnea testing have changed how your team monitors patients during the brain death confirmation process?
2The apnea test is a critical step in confirming brain death — can you explain how ORI monitoring, which this study investigated, might make that test safer or more informative for my loved one compared to relying only on arterial blood gas draws?
3This study was observational and focused on measuring a relationship between two monitoring tools rather than testing a new treatment — does that mean the findings are mainly about improving how clinicians watch over the patient during the apnea test, rather than changing the outcome itself?
4Since the trial has been completed, have the results been published or shared yet, and would it be worth reviewing them together to understand what they mean for how brain death is assessed here?
5Are there situations where the ORI sensor might not give reliable readings during an apnea test, and how does your team decide when to rely on it versus traditional arterial blood gas results?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Correlation between Oxygen Reserve Index (ORI) and arterial PaO2 during apnea test

Timeframe: Before and at specific intervals during the apnea test

Trial details

NCT IDNCT06983990

SponsorBursa Yuksek Ihtisas Training and Research Hospital

Sponsor typeOTHER_GOV

Study typeOBSERVATIONAL

Primary completion2025-06-01

View on ClinicalTrials.gov More Brain Death trials