RecruitingEarly Phase 1

The Kidney's Response to Exercise in Heat, and the Impact of Vitamin B3 on This Response

United States28 participantsStarted 2026-01-26

Plain-language summary

The goal of this clinical trial is to learn about the processes occurring in the kidneys while under heat stress in healthy volunteers. The main questions it aims to answer are: * How do the chemicals produced by the body change under conditions of higher versus lower heat stress? * What role does a specific area of the body's metabolism, known as NAD+ metabolism, play in the body's response to heat stress, and can this response be modified by taking vitamin B3?

Who can participate

Age range18 Years – 45 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Healthy volunteer * Any race * Estimated glomerular filtration rate greater than 90 ml/min/1.73m2 * Urine albumin/creatinine ratio less than 30mg/g * Nonsmoker * No regular dietary supplements, particularly vitamin B3 * Physically fit, defined as having a VO2 max of between 35 and 60mL/kg/min Exclusion Criteria: * Medical condition preventing safe participation in exercise during heat * Allergy to Vitamin B3 * Severe food allergies or dietary restrictions that would preclude eating the planned study diet without major modifications

What they're measuring

Urinary neutrophil gelatinase-associated lipocalin

Timeframe: Pre- and immediately post- heat stress exposure

Urinary TIMP2 (tissue inhibitor of metalloproteinase-2) and IGFBP7 (insulin-like growth factor-binding protein 7)

Timeframe: Pre- and immediately post- heat stress exposure

Trial details

NCT IDNCT06983730

SponsorBeth Israel Deaconess Medical Center

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2028-06

Contact for this trial

Nathan H Raines, MD MPH

703-927-0992 nraines@bidmc.harvard.edu

View on ClinicalTrials.gov More Heat Strain trials