CompletedNot Applicable

Euthyroid Sick Syndrome in Obesity Hypoventilation Syndrome

Egypt49 participantsStarted 2021-09-01

Plain-language summary

The goal of this observational study is to learn about the frequency and clinical impact of Euthyroid Sick Syndrome (ESS) in patients with Obesity Hypoventilation Syndrome (OHS) who are admitted to the intensive care unit (ICU) for acute respiratory failure. The main question it aims to answer is: How common is ESS in critically ill OHS patients, and does it affect the severity of illness and ICU outcomes? Participants with OHS who are admitted to the ICU will have blood tests for thyroid hormone levels (TT3, TT4, and TSH) within 24 hours of admission. Researchers will compare illness severity, oxygen levels, need for breathing support, ICU stay duration, and outcomes between those with and without ESS.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age ≥ 18 years * Diagnosis of Obesity Hypoventilation Syndrome (OHS), either pre-existing or newly established during ICU admission * Admitted to the intensive care unit (ICU) with acute hypercapnic respiratory failure, defined as: * Arterial pH \< 7.35 * PaCO₂ \> 45 mmHg * Thyroid function tests performed within 24 hours of ICU admission * Written informed consent provided by patient Exclusion Criteria: * Known history of thyroid disease (e.g., hypothyroidism, hyperthyroidism, thyroiditis, central hypothyroidism) * Presence of acute conditions known to affect thyroid function tests, including: * Sepsis * Pneumonia * Active malignancy * Liver cirrhosis * Kidney failure * Heart failure * Use of medications affecting thyroid function, including: * Corticosteroids * Amiodarone * Iodinated contrast agents

What they're measuring

ICU Mortality

Timeframe: During ICU stay (assessed up to 28 days)

Trial details

NCT IDNCT06983418

SponsorMansoura University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2023-10-30