RecruitingPhase 2

Effect of Topical Bromelain Versus Topical Corticosteroids in the Management of Oral Lichen Planus

Egypt42 participantsStarted 2026-02-18

Plain-language summary

Bromelain, an enzyme extract derived from pineapples, has shown promise due to its anti-inflammatory and wound-healing properties. However, its efficacy in treating oral mucosal ulcers remains unexplored. This study aims to provide clinical evidence on the efficacy of bromelain for managing OLP, potentially offering a safer and more effective treatment option.

Who can participate

SexALL

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Inclusion Criteria: * Patients suffering from symptomatic OLP * Patients free from any visible oral lesions other than OLP. * Patients who agreed to take the supplied interventions. * Patient who will agree to participate in the study. * Patients who will accept to sign the informed consent. Exclusion Criteria: * Patients suffering from any systemic disease. * Treatment with any systemic treatment such as systemic steroids, other immunosuppressive drugs or non-steroidal anti-inflammatory drugs at least eight weeks. * Treatment with any oral topical medications for at least four weeks prior to the study. * Pregnant and lactating mothers.

What they're measuring

Clinical improvement

Timeframe: Recorded at baseline, and weekly for 4 weeks

Trial details

NCT IDNCT06981767

SponsorCairo University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-05-15

View on ClinicalTrials.gov More Oral Lichen Planus trials