RecruitingPhase 1/2

Safety and Efficacy of hUC-MSC for the Treatment of Cartilage Damage in the Knee Joint

Germany55 participantsStarted 2025-11-10

Plain-language summary

Testing the safety and efficacy of MSC from umbilical cord tissue (UC-MSC) for the treatment of cartilage damage in the knee joint

Age range18 Years – 60 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

✕. Post-menopausal (12 months natural amenorrhea)
✕. Post-operative (6 weeks after bilateral ovariectomy with or without hysterectomy or bilateral salpingectomy)
✕. Presence of a negative pregnancy test (urine, not older than 14 days on the day of surgery) and willingness to regularly and correctly use a contraceptive method with a Pearl Index \< 1 % per year:
✕.1 Combined (oestrogen and progestogen-containing) hormonal contraception 3.2 Hormonal contraception containing progestogens (oral, injected, implanted) 3.3 IUD (hormonal IUD, copper IUD)
✕. Sexual abstinence
✕. Vasectomy of the partner

Proportion of patients with a serious adverse event within 24 months after surgery

Timeframe: within 24 months after surgery

NCT IDNCT06981741

SponsorBIONCaRT GmbH

Sponsor typeINDUSTRY

Study typeINTERVENTIONAL

Primary completion2027-11

Kristina Thamm, PhD