This study aims to investigate the intestinal mucosal expression of key inflammatory markers, namely Interleukin-1 (IL-1), Interleukin-18 (IL-18), and Caspase-1, in patients with Familial Mediterranean Fever (FMF). FMF is an autoinflammatory disorder characterized by recurrent episodes of fever and serosal inflammation. Recent studies suggest a possible role of intestinal immune activation in the disease pathogenesis, particularly through inflammasome-related cytokines. To better understand mucosal involvement in FMF, immunohistochemical staining for IL-1, IL-18, and Caspase-1 will be performed on intestinal biopsy samples obtained during routine endoscopic procedures. The staining intensity and distribution patterns will be evaluated and compared with age- and sex-matched healthy controls. The findings may help clarify mucosal inflammatory pathways involved in FMF and provide insight into novel therapeutic targets.
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Level of IL-1 in Mucosal Biopsies (Semi-Quantitative Score)
Timeframe: Single time point, Day 1 (during biopsy analysis)
Level of IL-18 in Mucosal Biopsies (Semi-Quantitative Score)
Timeframe: Single time point, Day 1 (during biopsy analysis)
Caspase-1 Expression in Mucosal Biopsies (Semi-Quantitative Score)
Timeframe: Single time point, Day 1 (during biopsy analysis)