CompletedNot Applicable

Non-randomized Clinical Trial on Cognitive Stimulation With Virtual Reality in Patients With Mild Cognitive Impairment

Spain70 participantsStarted 2024-10-04

Plain-language summary

The purpose of this study is to find out if adding virtual reality (VR) to a cognitive training program helps improve cognitive performance in older adults with mild cognitive impairment (MCI). In this study, all participants will take part in a 12-week computer-based cognitive rehabilitation program. One group will also use immersive VR for 15-20 minutes at the end of each session. Participants will attend 2 sessions per week, completing at least 20 sessions and up to 22, depending on the clinic's schedule. Researchers will measure changes in attention, memory, and thinking skills using standard cognitive tests. They will also collect feedback on how participants experience the VR exercises.

Who can participate

Age range

60 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age between 60 or older * Clinical diagnosis of mild cognitive impairment (MCI) * Preserved autonomy in basic and instrumental activities of daily living * MoCA score between 18 and 26 * Ability to use a computer interface with or without assistance * Capacity to understand and sign informed consent Exclusion Criteria: * Diagnosis of dementia (MMSE \< 18 or clinical judgment) * Severe visual or hearing impairment affecting task participation * History of epilepsy, vertigo, or conditions contraindicating VR use * Severe psychiatric or neurological illness (e.g., major depression, Parkinson's disease) * Enrollment in other cognitive training programs during the study period

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1This trial used virtual reality for cognitive stimulation in people with mild cognitive impairment — do you think this kind of approach could be appropriate for my situation, or would a more established therapy be a better starting point for me?
2Since this trial has already been completed, have the results been published yet, and if so, did the VR cognitive stimulation show meaningful improvements on the memory and thinking tests they used, like the MoCA or the Trail Making Test?
3This was a non-randomized trial, which I understand means there was no comparison group — how does that affect how confident we can be in any positive findings, and what would it take to know this approach truly works?
4The trial measured things like short-term memory, processing speed, and daily functioning skills — given how my own cognitive symptoms present, which of those areas are most relevant to track for me, and how would we know if any intervention is helping?
5Are there currently any standard-of-care options or other ongoing trials for mild cognitive impairment that I should be weighing alongside what this completed VR study found?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Global Cognition as Measured by the Montreal Cognitive Assessment (MoCA)

Timeframe: Baseline and immediately post-intervention (Week 12, within 1 week after last session)

Global Cognition as Measured by the Mini-Mental State Examination (MMSE)

Timeframe: Baseline and immediately post-intervention (Week 12, within 1 week after last session)

Short-Term Memory as Measured by the Digit Span Test (Forward Span)

Timeframe: Baseline and immediately post-intervention (Week 12, within 1 week after last session)

Working Memory as Measured by the Digit Span Test (Backward Span)

Timeframe: Baseline and immediately post-intervention (Week 12, within 1 week after last session)

Visuospatial Attention as Measured by the Trail Making Test Part A (TMT-A)

Timeframe: Baseline and immediately post-intervention (Week 12, within 1 week after last session)

Executive Function as Measured by the Trail Making Test Part B (TMT-B)

Timeframe: Baseline and immediately post-intervention (Week 12, within 1 week after last session)

Trial details

NCT IDNCT06977815

SponsorBadalona Serveis Assistencials

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-04-29

View on ClinicalTrials.gov More Mild Cognitive Impairment trials