Promoting Healthy Children and Youth

Inclusion Criteria: * Aged 12 to \< 18 years at screening * BMI \>/= 95th percentile based on age and sex Exclusion Criteria: * Diabetes (type 1 or 2) due to safety concerns about properly surveiling glycemic control virtually * Current or recent (\< 6 months prior to screening) use of obesity medications * Previous metabolic/bariatric surgery * Current or recent (\< 6 months prior to screening) use of medication(s) to treat insulin resistance * Hypertension * Hypercholesterolemia * History of treatment with growth hormone * Eating disorder diagnosis * Major psychiatric disorder * Unstable clinically-diagnosed depression * History of suicide attempt * History of suicidal ideation or self-harm within 30 days of screening * Current pregnancy or plans to become pregnant * Tobacco use * Uncontrolled hypertension * Diagnosis of monogenic obesity * History of cholelithiasis without cholecystectomy * Untreated thyroid disorder * History of pancreatitis * Personal/family history of medullary thyroid carcinoma and/or multiple endocrine neoplasia type 2