Two drugs called Idetrexed and olaparib are being evaluated. Idetrexed is a type of drug called an "aFR-targeted thymidylate synthase inhibitor". Idetrexed has been designed to selectively target cancer cells that have a protein called folate receptor on the surface of cancer cells. Thymidylate synthase is key to cancer cells for creating new DNA when they multiply. Blocking the action of thymidylate synthase with a drug like Idetrexed may therefore stop cancers from growing by damaging DNA in cancer cells. Olaparib is a type of drug called a "PARP inhibitor". It prevents cells repairing DNA damage. This leads to cells dying. Combining Idetrexed and olaparib should increase the number of cancer cells dying, especially those cells that have a lot of folate receptors. Cancer cells with a high number of folate receptors should be targeted more than normal healthy cells.
Age range
18 Years
Sex
FEMALE
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Propose a recommended dose/schedule for Phase II evaluation of the combination of Idetrexed and Olaparib
Timeframe: End of Cycle 2 (each cycle is 28 days)
Assess the safety and toxicity profile of Idetrexed and Olaparib
Timeframe: End of Cycle 6 (each cycle is 28 days)
Evaluate the preliminary anti-tumour activity of the combination of Idetrexed and Olaparib in alpha folate receptor overexpressing high grade serous ovarian cancer
Timeframe: Until patient withdraws due to radiological progression, or begins new line of therapy.