RecruitingPhase 3

Non-Narcotic Pain Control After ACL Reconstruction

United States30 participantsStarted 2025-07-15

Plain-language summary

This is a double-blind randomized controlled trial of standard of care therapy, either oral ketorolac (experimental group) or oral oxycodone (control group) to demonstrate efficacy in reducing the percentage of narcotic doses taken and documenting the number of patients with no exposure to any narcotics (take zero oxycodone) after undergoing primary knee ACL reconstruction outpatient surgery.

Who can participate

Age range15 Years – 55 Years

SexALL

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Inclusion Criteria: * Provision of signed and dated informed consent form * Stated willingness to comply with all study procedures and availability for the duration of the study * Male or female, aged 15-55 years * Primary Autograft ACL surgery * Ability to take oral medication and willingness to patriciate in a virtual 1 and 2 week follow-up pill counts Exclusion Criteria: * Provision of signed and dated informed consent form * Stated willingness to comply with all study procedures and availability for t the duration of the study * Male or female, aged 15-55 years * Primary Autograft ACL surgery * Ability to take oral medication and willingness to patriciate in a virtual 1 and 2 week follow-up pill counts

What they're measuring

Primary outcome

Timeframe: 30 days

Trial details

NCT IDNCT06973785

SponsorThe Cleveland Clinic

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-09-30

Contact for this trial

Jennifer Baldwin

216.390.5833 baldwij3@ccf.org

View on ClinicalTrials.gov More ACL - Anterior Cruciate Ligament Rupture trials