Hydrogen-Rich Water and Metabolic Health in Adults: A 12-Week Randomized Trial (NCT06968715) | Clinical Trial Compass
CompletedNot Applicable
Hydrogen-Rich Water and Metabolic Health in Adults: A 12-Week Randomized Trial
Serbia40 participantsStarted 2025-04-01
Plain-language summary
The HYDRO-RESPOND trial is a 12-week randomized controlled study investigating the effects of daily hydrogen-rich water (HRW) consumption on body composition and metabolic biomarkers in adults diagnosed with metabolic syndrome. The study also explores whether individual differences in baseline breath hydrogen levels influence response to HRW. Participants are randomly assigned to receive either HRW or a placebo, with outcomes including changes in body fat, waist circumference, glucose metabolism, lipid profiles, and inflammatory markers. The trial aims to determine the therapeutic potential of HRW and identify predictors of individual responsiveness.
Who can participate
Age range
30 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age 30-65 years
* Metabolic syndrome (NHS) (at least 3 of the 5 following criteria):
* Waist circumference of ≥ 102 cm in men and ≥ 88 cm in women
* Hypertriglyceridemia (≥ 1.695 mmol/L)
* Low HDL-C (\< 1.04 mmol/dL in men and \< 1.30 mmol/dL in women)
* High blood pressure (\> 130/85 mmHg)
* High fasting glucose (\> 6.1 mmol/L)
* Not physically active
* Informed consent signed
Exclusion Criteria:
* Major chronic disease and acute injuries
* History of dietary supplement use during the past 4 weeks
* History of metabolism-modulating pharmaceuticals use during the past 4 weeks
* No consent to randomization
* Participation in other studies
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Waist circumference
Timeframe: Change from baseline waist circumference at 12 weeks
Trial details
NCT IDNCT06968715
SponsorUniversity of Novi Sad, Faculty of Sport and Physical Education