This proof-of-concept trial investigates whether high-intensity, low-frequency repetitive transcranial magnetic stimulation (rTMS) targeting the right dorsolateral prefrontal cortex (DLPFC) can improve autonomic cardiac regulation in women with recurrent pregnancy loss (RPL) and anxiety. The study explores the lateralised function of the DLPFC in emotional and autonomic control and tests a novel neuromodulation-based strategy to relieve anxiety and sympathetic overactivation.
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Change in baseline-corrected heart rate across stimulation intensities
Timeframe: During six consecutive stimulation trains (each 60 seconds; intensities increasing from 100% to 150% RMT)
Change in heart rate variability (HRV) spectral power at 0.0167 Hz during rTMS
Timeframe: During six consecutive stimulation trains (each 60 seconds; intensities increasing from 100% to 150% RMT