CompletedNot Applicable

The Relationship Between Delirium and BDNF in Coronary Artery Bypass Graft Surgery

Poland107 participantsStarted 2021-07-01

Plain-language summary

This study is aimed at finding a correlation between postoperative delirium occurrence, severity and duration after cardiac surgery and the level of brain-derived neurotrophic factor (BDNF) in plasma as a marker of brain injury induced by cardio-pulmonary by-pass and its association with genetic predisposition in patients undergoing coronary artery bypass grafting (CABG) carrying BDNF gene polymorphism (Val66Met).

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Age \> 18 years.
✓. Planned coronary artery bypass grafting (CABG) procedure with the use of cardiopulmonary by-pass (CPB).
✓. Ability to understand and sign an informed consent form.

Exclusion criteria

✕. Emergency surgery.
✕. Previous known cognitive disorders: Mini Mental State Examination (MMSE) score \<15.
✕. Baseline delirium (positive CAM test prior to surgery).
✕. Diagnosis of psychiatric syndromes in the past - i.e. depression, dementia, psychosis or schizophrenia.
✕. Inability to understand Polish language.
✕. Inability to give and sign informed consent due to auditory or visual dysfunction.

What they're measuring

The main aim of the study will be to assess the correlation between brain function disorders, defined as abnormal BDNF levels, and postoperative delirium.

Timeframe: Up to a year after the procedure.

Trial details

NCT IDNCT06967779

SponsorPomeranian Medical University Szczecin

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2023-07-01

View on ClinicalTrials.gov More Delirium - Postoperative trials