CompletedNot Applicable

Rebound Pain After Peripheral Nerve Blocks in Total Knee Arthroplasty

Turkey (Türkiye)294 participantsStarted 2025-05-21

Plain-language summary

This prospective observational study aims to determine the incidence and clinical impact of rebound pain after peripheral nerve blocks in patients undergoing total knee arthroplasty. Rebound pain is defined as a sudden, severe pain (NRS ≥7) emerging after block resolution. Primary outcome is the incidence of rebound pain; secondary outcomes include pain severity, rescue analgesia use, nausea, vomiting, sleep quality, and patient satisfaction.

Who can participate

Age range18 Years – 70 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age between 18 and 70 years * ASA physical status I to III * Scheduled for elective unilateral total knee arthroplasty under spinal anesthesia * Peripheral nerve block (PNB) planned as part of multimodal analgesia * Ability to understand and provide written informed consent * Willingness and ability to complete the postoperative pain diary Exclusion Criteria: * Known allergy or hypersensitivity to local anesthetics * Contraindication to regional anesthesia * ASA physical status IV or higher * Neurological or psychiatric disorders interfering with study participation or pain reporting * Use of anticoagulants or presence of coagulopathy * Use of medications that may alter pain perception or rebound pain response * Local infection at the block site * Emergency surgeries * Inability or unwillingness to complete the postoperative pain diary or follow-up

What they're measuring

Incidence of Rebound Pain After Peripheral Nerve Block

Timeframe: Within 48 hours after surgery

Trial details

NCT IDNCT06966011

SponsorKonya City Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-03-03