Intermittent Hypoxia-Hyperoxia Combined With Physical Therapy for Knee Osteoarthritis

Inclusion Criteria: * Participants aged 45 and above. * Participants (both male and female) with knee pain for 3 months or more with any three of the following six items: age of 50 years or more, crepitations, enlarged bone, no palpable warmth, morning stiffness for less than 30 minutes, and bony tenderness. * Patients who can walk and have a minimum score of 4 on the Numeric Pain Rating Scale. * Participants who have intact cognition with a score of 24 and above on Mini Mini- Mental State examination. * Participants able to walk independently for at least 45 meters in the 6-minute walk test. * Participants having a recent X-ray (done within the past 3 months). Exclusion Criteria: * Patients with hip or knee arthroplasty. * Participants with above or below knee surgery or radiating pain to the lower limb. * Patients with history of epilepsy, pregnancy * Diagnosed neurological condition that affects lower-limb strength or walk (e.g., stroke/ basal ganglia dysfunction/ trauma) * Patients who refused to participate in the study or to be randomly allocated. * Patients receiving steroids or any medicine other than that prescribed by the screening orthopaedic surgeon.