Impact of Sodium Glucose Co-transporter 2-Inhibitors on Clinical Outcome and Left Ventricular Fun… (NCT06964607) | Clinical Trial Compass
CompletedNot Applicable
Impact of Sodium Glucose Co-transporter 2-Inhibitors on Clinical Outcome and Left Ventricular Function in Patients Presented by Acute Myocardial Infarction
Egypt80 participantsStarted 2023-04-01
Plain-language summary
This study aimed to assess the effect of adding sodium glucose co-transporter two inhibitors on clinical outcome and left ventricular function in patients with acute myocardial Infarction.
Who can participate
Age range18 Years
SexALL
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Inclusion Criteria:
* Age ≥ 18 years.
* Both sexes.
* Recent myocardial infarction.
Evidence of significant myocardial necrosis defined as a rise in troponin level \> 99th Percentile ULN (upper limit of normal). In addition, at least one of the following criteria must be met:
* Symptoms of ischemia.
* ECG changes indicative of new ischemia (new ST-T changes or new Left bundle branch block (LBBB))
* Imaging evidence of new regional wall motion abnormality.
* Estimated Glomerular Filtration Rate (eGFR)\> 30 ml/min/1.73 m2.
* Blood pressure before first drug dosing \>110/70 mmHg.
Exclusion Criteria:
* Known allergy to sodium/glucose cotransporter 2 (SGLT2) inhibitors.
* Patients with poor echocardiographic views.
* Hemodynamic instability as defined by intravenous administration of catecholamine.
* \>1 episode of severe hypoglycemia within the last 6 months under treatment with insulin or sulfonylurea.
* Pregnant women or females of childbearing age without adequate contraceptive methods.
* Acute symptomatic urinary tract infection (UTI) or genital infection
* Patients currently being treated with any SGLT-2 inhibitor or having received treatment with any SGLT-2 inhibitor within the 4 weeks before the screening visit.
* Patient with a previous myocardial ischemic event or previous heart failure.
* Patients with significant valvular dysfunction.