RecruitingNot Applicable

Test of Target Engagement of Ambiguity Aversion

United States140 participantsStarted 2025-07-07

Plain-language summary

The present work aims to test whether a single session intervention alters ambiguity aversion, both in terms of people's decision making and their brain responses to ambiguous choices.

Who can participate

Age range25 Years – 60 Years

SexALL

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Inclusion criteria

✓. Ages 25 to 60
✓. Right-handed
✓. Ability to read and write English
✓. Capacity to provide informed consent
✓. Intolerance of uncertainty score ≥ -0.5 standard deviation below the mean (31st percentile)

Exclusion criteria

✕. Personal history of psychosis, mania, or hypomania
✕. Personal history of autism spectrum disorder
✕. IQ \< 80 as determined by the Wechsler Test of Adult Reading
✕. Head injury with greater than 120 seconds loss of consciousness
✕. Neurological condition (e.g., epilepsy, Parkinson's, cerebral palsy, history of stroke)
✕. Currently pregnant
✕. Use of any implanted electrical device (e.g., pacemaker, spinal stimulator, vagal nerve stimulator, Inspire sleep apnea device, etc.).

What they're measuring

Beck Hopelessness Scale-4 (BHS-4)

Timeframe: 1 hour

Behavioral ambiguity aversion

Timeframe: 1 hour

Event-related potential responses to ambiguous choices

Timeframe: 1 hour

Trial details

NCT IDNCT06962527

SponsorNorthwestern University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2029-07-01

Contact for this trial

Brent I Rappaport, Ph.D.

(312) 585-6603 decisionmaking@northwestern.edu

View on ClinicalTrials.gov More Intolerance of Uncertainty trials