Combining Electrical Impedance Tomography and Thoracic Ultrasound Toinvestigate Dynamic Changes
50 participantsStarted 2025-05-19
Plain-language summary
1. To evaluate the dynamic changes of lung ultrasound during electrical impedance tomography (EIT) PEEP titration and across the first week of ARDS.
2. To asses respiratory effort by diaphragmatic function, esophageal pressure, and EIT (Pendelluft phenomenon), and hyperinflammatory biomarkers, to predict P-SILI.
3. To develop predictive models for weaning success based on integrated EELI and thoracic ultrasound.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adult \>18 y/o.
* Patient intubated and receiving mechanical ventilation \> 24 hours.
* Admitted into ICU, diagnosed as moderate or severe ARDS (ICD-10-CM: J80) according to Berlin definition.
Exclusion Criteria:
* Presence of Implanted Electronic Devices (pacemakers, implantable cardioverter-defibrillators).
* Pregnancy.
* No consent/inability to obtain consent and appropriate legal representative not available.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This study combines two monitoring tools — electrical impedance tomography and thoracic ultrasound — to observe how the lungs change over time in ARDS; can you explain what these tests would actually involve for me or my loved one, and how often they would be performed during a hospital stay?
2Since this trial is listed as 'not yet recruiting,' is there a realistic timeline for when it might open, and would it make sense to consider enrolling in a different active ARDS study in the meantime?
3This appears to be an observational study measuring lung changes rather than testing a new treatment — does that mean standard ARDS care would continue unchanged, and what, if anything, would be different about my care if I participated?
4Because this trial is phase 'not applicable,' which often means it's not testing a drug or device for direct benefit, what would my family member realistically gain from participating compared to receiving standard care alone?
5Given that ARDS can progress very rapidly, how would the timing and eligibility requirements of this study affect critical treatment decisions that might need to happen quickly?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
ARDS
Timeframe: From enrollment to the end of treatment at 1 weeks.