Effect of Dexmedetomidine on Acute Kidney Injury After Ascending Aortic Surgeries (NCT06958367) | Clinical Trial Compass
Active — Not RecruitingPhase 1
Effect of Dexmedetomidine on Acute Kidney Injury After Ascending Aortic Surgeries
Egypt78 participantsStarted 2025-11-01
Plain-language summary
Acute kidney injury (AKI) is a frequent and serious complication after ascending aortic surgeries requiring cardiopulmonary bypass (CPB). Dexmedetomidine, a selective α-2 adrenoreceptor agonist, may reduce AKI because of its sympatholytic and anti-inflammatory effects against ischaemia reperfusion injury. We investigate the effect of dexmedetomidine administration on AKI after ascending aortic surgeries requiring CPB in a placebo-controlled randomised controlled trial.
Who can participate
Age range
21 Years – 70 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* ●Age: 20-70 yrs
* Scheduled for aortic surgery under CPB
Exclusion Criteria:
* ●Patient refusal to participate
* Congestive heart failure with a left ventricular ejection fraction \<45%
* Uncontrolled arrhythmia combined with unstable hemodynamics
* Acute coronary syndrome.
* Preoperative elevated kidney function (serum urea and serum creatinine). Use of ventricular assist devices
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This is listed as a Phase 1 trial for dexmedetomidine — what does that mean for how much is already known about its safety in this specific context of ascending aortic surgery?
2Since the trial is 'active but not recruiting,' is there any chance I could still be considered, or would my doctor recommend waiting for a future study that's open to new participants?
3How would my kidney function be monitored during this trial, and what would happen if signs of acute kidney injury appeared while I was receiving dexmedetomidine?
4Given that this trial involves major heart surgery on the ascending aorta, how does my doctor weigh the added complexity of participating in a research study against just focusing on the surgery itself and standard post-operative care?
5Are there already established approaches to protecting kidney function after ascending aortic surgery that I should consider before looking at an experimental option like this one?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
measurement of kidney function
Timeframe: Serum creatinine levels will beassessed before surgery, at least once a day until postoperative day 5