Analysis of Salivary Proteins in Young Children as an Device to Improve Caries Risk Assessment (NCT06957509) | Clinical Trial Compass
RecruitingNot Applicable
Analysis of Salivary Proteins in Young Children as an Device to Improve Caries Risk Assessment
Sweden100 participantsStarted 2025-04-04
Plain-language summary
The goal of this observational study is to learn if the composition of salivary proteins in 3-year-old children, from communities with documented varying caries risks, can be used to identify future diagnostic predictors for caries risk.
The main question to answer is:
• Can the host´s salivary protein profile (expression and abundance) show a correlation with the caries prevalence between the individuals in the different study cohorts?
Two cohorts of children with different documented demographic characteristics in the region of Stockholm (Sweden) will be examined.
Participants will be asked to provide saliva samples and undergo clinical oral examinations conducted by trained dental practitioners.
Who can participate
Age range
3 Years – 3 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* 3-year-old children residing in the areas served by Folktandvården Danderyd and Järva, respectively
* Written consent, signed by both parents (guardians)
Exclusion Criteria:
* children older than three years
* medication intake, and antibiotic use at the time of examination
* children who have consumed food, drink, or used oral hygiene products within 2 hours before the dental visit
* children who appear uncooperative during saliva sampling
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Differential protein expression across caries severity levels