The Effect of Dexamethasone Submucosal Injection After Surgical Extraction of Lower Impacted Thir… (NCT06953440) | Clinical Trial Compass
RecruitingPhase 4
The Effect of Dexamethasone Submucosal Injection After Surgical Extraction of Lower Impacted Third Molars on Trismus and Edema
Saudi Arabia66 participantsStarted 2024-02-01
Plain-language summary
This clinical trial aims to investigate whether dexamethasone decreases edema and trismus in adults undergoing lower third molar surgical extraction.
The main question it aims to answer is:
Does dexamethasone submucosal injection have a positive impact on trismus and edema after third molar surgery compared to conventional postoperative prescription?
Participants will:
* Be administered with dexamethasone submucosal injection or a placebo after the surgery.
* Visit the clinic three times the week after the extraction for follow-up.
Who can participate
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients with impacted lower third molars requiring surgical extraction.
* Adults over the age of 18 years old.
* American Society of Anaesthesiologists (ASA) 1, and ASA 2
Exclusion Criteria:
* Patients with preoperative intraoral or extraoral swelling.
* Patients requiring simple extraction (Class I group A according to Pell and ---Gregory classification).
* Patients with uncontrolled systemic disease such as uncontrolled diabetic - patients.
* Patients who are allergic to corticosteroids.
* Patients who are contraindicated to use corticosteroids such as uncontrolled diabetic patients, and osteoporotic patients.
* Patients who require extraction of additional teeth at the same visit.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Trismus and Swelling
Timeframe: From the day of extraction, the 2nd day of surgery, 4th day, and 7th day of surgery.