RecruitingNot Applicable

Intraoperative Hypotension in Pancreatoduodenectomy: A Randomized Trial of General Versus Combined Anesthesia

Mexico206 participantsStarted 2025-04-07

Plain-language summary

This randomized clinical trial compares the hemodynamic effects of general anesthesia versus combined general anesthesia (thoracic epidural) in patients undergoing pancreatoduodenectomy. The primary aim is to assess the incidence of intraoperative hypotension and related adverse events. Secondary outcomes includes vasopressor requirements, transfusion needs, postoperative complications, intensive care unit admission, hospital length of stay, and mortality.

Who can participate

Age range18 Years

SexALL

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Inclusion Criteria: * Signed written informed consent. * Patients scheduled for elective pancreatoduodenectomy at National Institute of Medical Sciences and Nutrition Salvador Zubirán. * No contraindications for neuroaxial anesthesia (epidural catheter placement), including: * Generalized or localized infection at the puncture site. * Thrombocytopenia. * Coagulation disorders. * Intracranial hypertension. * Patient refusal. Exclusion Criteria: * Age under 18 years. * Pregnancy. * Inability to randomize the case due to specific circumstances (such as contraindications to epidural use), resulting in non-eligibility based on participation criteria.

What they're measuring

Incidence of Intraoperative Hypotension

Timeframe: From induction of anesthesia to end of surgery (intraoperative period).

Trial details

NCT IDNCT06953193

SponsorInstituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2030-01-07

Contact for this trial

Rafael P. Leal Villalpando, MD

5554 87 09 00 rafael.lealv@incmnsz.mx

View on ClinicalTrials.gov More Pancreatic Neoplasms trials