This randomized controlled trial enrolled women of advanced maternal age (≥35 years) undergoing ART, who were allocated to an intervention group (oral nicotinamide riboside, NR) or a control group (oral vitamin E, VitE) for a 2-month pre-ART intervention. The study systematically evaluated NR's regulatory effects on ovarian function and ART outcomes by measuring NAD+ levels in ovarian granulosa cells (GCs) and peripheral blood mononuclear cells (PBMCs), anti-Müllerian hormone (AMH) concentrations.
Age range
35 Years – 42 Years
Sex
FEMALE
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Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Follicle Counting
Timeframe: At the time of the first medication administration and on days 2-3 of the menstrual cycle during the second month of medication
Serum AMH Levels
Timeframe: At the time of the first medication administration and on days 2-3 of the menstrual cycle during the second month of medication
Serum FSH Levels
Timeframe: At the time of the first medication administration and on days 2-3 of the menstrual cycle during the second month of medication
ART outcomes assessed by the number of clinically viable embryos and clinical pregnancy rates
Timeframe: From embryo transfer to the 14-day post-transfer clinical observation period
Serum LH Levels
Timeframe: At the time of the first medication administration and on days 2-3 of the menstrual cycle during the second month of medication
Serum P Levels
Timeframe: At the time of the first medication administration and on days 2-3 of the menstrual cycle during the second month of medication
Serum E2 Levels
Timeframe: At the time of the first medication administration and on days 2-3 of the menstrual cycle during the second month of medication
Serum Testosterone levels
Timeframe: At the time of the first medication administration and on days 2-3 of the menstrual cycle during the second month of medication
Antral Follicle Count Retrived
Timeframe: Immedietly after oocyte retrived
Oocytes Retrived
Timeframe: Immedietly after oocyte retrived
NAD+ Levels in PBMCs
Timeframe: At the time of the first medication administration and on days 2-3 of the menstrual cycle during the second month of medication
NAD+ Levels in GCs
Timeframe: Immedietly after oocyte retrived
Number of Day 3 embryos
Timeframe: Day 3 of Embryo Culture
Number of Day 3 top-quality embryos
Timeframe: Day 3 of Embryo Culture
Number of transferable embryos
Timeframe: Day 3 of Embryo Culture
Blastocyst Formation Rate
Timeframe: Day 6 of Embryo Culture