The Role of Melatonin as an Adjuvant Therapy in Childhood Pneumonia (NCT06949904) | Clinical Trial Compass
RecruitingPhase 1/2
The Role of Melatonin as an Adjuvant Therapy in Childhood Pneumonia
Pakistan60 participantsStarted 2025-05
Plain-language summary
The goal of this study is to compare the mean length of hospital stay between children with pneumonia receiving melatonin as an adjuvant therapy and those receiving standard of care alone.
The hypothesis is that combining oral melatonin with standard treatment can reduce the length of hospital stay as compared to standard of care alone.
The control group will receive standard treatment (antibiotic) while the intervention group will receive standard treatment plus melatonin for 14 days.
Who can participate
Age range
1 Month – 12 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* 1 month to 12 years
* Both genders
* Patient diagnosed as having pneumonia or severe pneumonia according to WHO definition
Exclusion Criteria:
* Hospitalized within 14 days prior to the study
* Known TB exposure
* Active varicella or herpes simplex infection
* Allergy to the study medication
* Currently taking melatonin
* Any non pneumonia acute medical illness which requires antibiotic treatment as per local standard of care
* Galactose intolerance, the lapp-lactase deficiency or glucose-galactose malabsorption
* Significant co-morbid disease: lung, cardiac, immune, liver, endocrine, neurological or psychiatric
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.