The aim of the study is first, to evaluate the clinical antibacterial efficacy of two different NaOCl concentrations (2,5% and 5%) under a predefined irrigant flow rate in teeth with pulp necrosis and apical periodontitis by using Real-time PCR. . Second, to evaluate the efficacy of final irrigation by assessing, if possible, a numerical definition for that "so called" as "copious irrigation". Besides the total microbial load, the antibacterial efficacy of final irrigation procedure against two different bacterial species (namely Pseudoramibacter alactolyticus and Treponema denticola) will also be examined.
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Reduction of total bacterial load after chemomechanical preparation using 2.5% and 5% NaOCl.
Timeframe: DAY 1: Immediately after chemomechanical preparation.
Reduction of total bacterial load after chemomechanical preparation using 2.5% and 5% NaOCl.
Timeframe: DAY 1: Immediately after final irrigation.
Clinical and radiographic treatment success.
Timeframe: 1 year post tratment.